Cialis is the commercial brand name for Tadalafil, a medication for treating erectile dysfunction. Together with Viagra, Cialis is a very popular option for men with ED problems. “The weekend pill” is a nickname of Cialis because the drug can have effects for more than 30 hours, compared to the 8 hours of its main competitors, Viagra and Levitra.
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Tadalafil works as a PDE5 inhibitor. In simple language, the drug blocks the degradative action for cyclic GMP, which is found in the smooth muscle of the wall of the arteries and the cells that line the blood vessels that supply blood to the penis. Because of that, Tadalafil is also used to treating hypertension.
The first company to research and develop Tadalafil was ICOS Corporation. Nowadays, Cilas is sold in yellow, film coated tablets in doses of 5, 10 and 20 mg. Another less well-known name of Tadalafil is Tadacip, which is manufactured and sold by an Indian pharmaceutical company, Cipla.
To understand how Cialis works to treat erectile dysfunction, we must learn about how penile erection works and how erectile dysfunction happens first. When blood vessels dilate and pump blood into the male sexual organ, an erection is achieved. Simultaneously, the blood vessels that pump out blood from the penis contract to keep the blood inside, therefore the erection can be maintained for a long time. All these things happen with the help of nitric oxide which was released into the penis when a man got sexually stimulated. Nitric oxide triggers the production of cGMP, which controls the dilation and contraction of blood vessels that pump blood in and out of the penis. Erectile dysfunction happens when another enzyme called phosphodiesterase-5 (PDE5) destroys cGMP, and thus turns the blood vessels back into normal size. As a PDE5 inhibitor, Tadalafil prolongs the duration of the effects of cGMP, which therefore maintains the erection.
The Food and Drug Administration of the US approved Cialis in 2003 for its use in treating erectile dysfunction and in 2009 for the treatment of pulmonary arterial hypertension. So normally, the drug is considered as safe. However, there are still many things to pay attention to when taking Cialis. According to the official instruction of Cialis, people who have existing heart, kidney and liver problems should avoid using Cialis. And there are several other side effects of Cialis have been reported. A sudden drop in blood pressure can happen if Cialis is taking with a nitrate medication. One of the serious side effects is the feeling of dizzy and nauseated during sexual activity. Numbness, pain in joints and limbs can also happen. Sometimes the erection can last for more than 4 hours even after ejaculation, and the erection can become quite painful. The blood flow to the optic nerve of the patient’s eyes can be disturbed which causes a sudden vision loss, but this is more likely to happen if the patient already have eye problems. If you experience any of these symptoms after taking Cialis, you should stop the medication immediately and seek medical help.
Hello, welcome. I am Peter Doherty, Australian physician from Melbourne. My goal is to provide you important information about Viagra and its substitutes.