Tadalafil is a medication that is effective in treating the symptoms of erectile dysfunction in men (ED) and helps enhance the male sexual performance by sustaining strong erections during sexual intercourse. Tadalafil can have various commercial names, the most popular being Cialis.
Cialis – Mechanism of action
Tadalafil has a mechanism of action that is similar to other drugs like Sildenafil or Vardenafil, which belong to a group of medications called PDE5 inhibitors. However, Tadalafil is known for its prolonged effects compared to the other two drugs.
Unlike Sildenafil (Viagra) or Vardenafil, which are effective only for a few hours, the effects of Tadalafil (Cialis) can last from 24 to 36 hours, and sometimes even more, depending on the individual metabolism. This has led many doctors to call Tadalafil the “weekend pill” due to its potent and prolonged erection-supporting effects. How can Tadalafil help a man achieve a potent erection if he suffers from erectile dysfunction?
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PDE5 inhibitor
Tadalafil works by blocking the action of PDE5, or phosphodiesterase type 5, which is an enzyme present in the tissues of the penis and exerts a specific function. When a man is sexually aroused, the nerve endings in the penis produce nitric oxide (NO), which acts as a messenger and stimulates an enzyme to produce an active chemical component called cGMP. This chemical is the active substance that directly acts on the blood vessels found in the cavernous bodies of the penis, causing their dilation, which allows for blood entry in the chambers of the cavernous bodies, resulting in an erection. cGMP, however, is destroyed by another enzyme called PDE5, which neutralizes its effects. Medical professionals believe that men who are unable to maintain an erection due to erectile dysfunction may have low amounts of cGMP, which can be addressed through the administration of a PDE5 inhibitor, such as Tadalafil. The medication blocks the destructive enzyme, and therefore stimulates the accumulation of active cGMP, which results in a prolonged, potent erection for an improved sexual life. Although drugs like Sildenafil or Vardenafil work in the exact same manner, their effects last for only a few hours, which requires a more frequent pill administration when compared to Tadalafil.
Cialis is approved for use in USA and Australia
Tadalafil has been extensively tested and it is approved as a great treatment for erectile dysfunction in men. It can also be used to address the symptoms of pulmonary hypertension, although this medical indication requires special medical approval. Tadalafil is very well tolerated by men, and the potential for side effects is low. However, Tadalafil may cause temporary and mild adverse effects, such as nausea, headaches, back pain or digestive disturbances. Talk to your doctor if you experience any side effects, and he or she can help adjust the dosage in a manner that minimizes the adverse effects.
Hello, welcome. I am Peter Doherty, Australian physician from Melbourne. My goal is to provide you important information about Viagra and its substitutes.